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Article

Synergistic role of three dimensional niche and hypoxia on conservation of cancer stem cell phenotype.

International journal of biological macromolecules - 1 Sept 2016

Gorgun Cansu, Ozturk Sukru, Gokalp Sevtap, Vatansever Seda, Gurhan S Ismet Deliloglu, Urkmez Aylin Sendemir

Abstract excerpt

Hypoxia is a pathalogical condition in which tissues are deprived of adequate oxygen supply. The hypoxia effect on tumors has a critically important role on maintenance of cancer stem cell phenotype. The aim of this study is to investigate the effects of hypoxia on cancer stem cells on three dimensional (3D) in vitro culture models. Osteosarcoma stem cells characterized by CD133 surface protein were isolated from...

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Identifiers

PMID: 26718870
DOI: 10.1016/j.ijbiomac.2015.12.053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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