Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CDX2 does not suppress tumorigenicity in the human gastric cancer cell line MKN45.

Oncogene - 30 Mar 2006

Dang L H, Chen F, Knock S A, Huang E H, Feng J, Appelman H D, Dang D T

Abstract excerpt

CDX2 is a Drosophila caudal-related homeobox transcription factor that is expressed specifically in the intestine. In mice, ectopic expression of CDX2 in the gastric mucosa gives rise to intestinal metaplasia and in one model, gastric carcinoma. In humans, increased CDX2 expression is associated with gastric intestinal metaplasia and tubular adenocarcinomas. These patterns of expression have shown that CDX2 is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to CDX2 Transcription Factor
Share to Cell Cycle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Division

Share to Homeodomain Proteins

Share to Recombination, Genetic

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Stomach Neoplasms

Source

Identifiers

PMID: 16331267
DOI: 10.1038/sj.onc.1209243

Genes

CDX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDX2 does not suppress tumorigenicity in the human gastric cancer cell line MKN45.PMID 16331267Read ↗

CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotypeSemantic proximity Read ↗

Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer.Semantic proximity Read ↗

Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-induced intestinal metaplastic mucosa.Semantic proximity Read ↗

The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non–cell-autonomous mechanismsSemantic proximity Read ↗

Nuclear transcription factor CDX2 inhibits gastric cancer‑cell growth and reverses epithelial‑to‑mesenchymal transition in vitro and in vivo.Semantic proximity Read ↗

Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and β-Catenin Activity in Colon Cancer CellsSemantic proximity Read ↗

Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines.Semantic proximity Read ↗

Genetic alterations of the Cdx2 gene in gastric cancer.Semantic proximity Read ↗

CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance.Semantic proximity Read ↗

CDX2 polymorphisms, RNA expression, and risk of colorectal cancer.Semantic proximity Read ↗

Homeosis and intestinal tumours in Cdx2 mutant mice.Semantic proximity Read ↗

Altered expression of CDX2 in colorectal cancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.