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Article

CDX2 polymorphisms, RNA expression, and risk of colorectal cancer.

Cancer research - 1 Jul 2005

Rozek Laura S, Lipkin Steven M, Fearon Eric R, Hanash Samir, Giordano Thomas J, Greenson Joel K, Kuick Rork, Misek David E, Taylor Jeremy M G, Douglas Julie A, Rennert Gad, Gruber Stephen B

Abstract excerpt

In adult mammals, CDX2 acts as a transcription factor and is expressed in intestinal epithelial cells. Down-regulation of CDX2 is frequently observed in colorectal cancer, suggesting its loss may cause dedifferentiation of gastrointestinal epithelial cells. However, it is not clear whether inherited variants of CDX2 are associated with risk of colorectal cancer. Using epidemiologic data and tumors from a...

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Identifiers

PMID: 15994917
DOI: 10.1158/0008-5472.CAN-04-3645

Genes

CDX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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