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Article

Unmutated proto-src coding region is tumorigenic if expressed from the promoter of Rous sarcoma virus: implications for the gene-mutation hypothesis of cancer.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1992

Wu Y, Zhou H, Duesberg P

Abstract excerpt

The transforming (onc) genes of oncogenic retroviruses share most or all of their coding sequences with normal cellular genes termed proto-onc genes. The viral genes differ from proto-onc genes in virus-specific promoters and in various point mutations and substitutions of cell-derived coding regions. In view of the structural similarities between viral oncogenes and cellular proto-onc genes, the hypothesis has...

Topics

Animals
Avian Sarcoma Viruses
Base Sequence
Cell Transformation, Viral
Chickens
DNA, Recombinant
DNA, Viral
Gene Expression Regulation, Neoplastic
Gene Expression Regulation, Viral
Genes, src

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Promoter Regions, Genetic

Proto-Oncogenes

Sarcoma, Experimental

Source

Open in PubMed Open full text

Identifiers

PMID: 1321438
DOI: 10.1073/pnas.89.14.6393
PMCID: PMC49507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1321438-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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