Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect.

doi:10.1007/s00439-005-0099-4

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Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect.

Human genetics - 1 Feb 2006

Chang Bao-Li, Lange Ethan M, Dimitrov Latchezar, Valis Christopher J, Gillanders Elizabeth M, Lange Leslie A, Wiley Kathleen E, Isaacs Sarah D, Wiklund Fredrik, Baffoe-Bonnie Agnes, Langefeld Carl D, Zheng S Lilly, Matikainen Mika P, Ikonen Tarja, Fredriksson Henna, Tammela Teuvo, Walsh Patrick C, Bailey-Wilson Joan E, Schleutker Johanna, Gronberg Henrik, Cooney Kathleen A, Isaacs William B, Suh Edward, Trent Jeffrey M, Xu Jianfeng

Abstract excerpt

Prostate cancer represents a significant worldwide public health burden. Epidemiological and genetic epidemiological studies have consistently provided data supporting the existence of inherited prostate cancer susceptibility genes. Segregation analyses of prostate cancer suggest that a multigene model may best explain familial clustering of this disease. Therefore, modeling gene-gene interactions in linkage...

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PMID: 16328469
DOI: 10.1007/s00439-005-0099-4

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