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Article

Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer: statistical evaluation of epistasis.

PloS one - 1 Jan 2014

Chen Li-Sheng, Fann Jean Ching-Yuan, Chiu Sherry Yueh-Hsia, Yen Amy Ming-Fang, Wahlfors Tiina, Tammela Teuvo L, Chen Hsiu-Hsi, Auvinen Anssi, Schleutker Johanna

Abstract excerpt

Understanding the impact of multiple genetic variants and their interactions on the disease penetrance of familial multiple prostate cancer is very relevant to the overall understanding of carcinogenesis. We assessed the joint effect of two loci on rs4242382 at 8q24 and rs10486567 at 7p15.2 to this end. We analyzed the data from a Finnish family-based genetic study, which was composed of 947 men including 228...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24586834
DOI: 10.1371/journal.pone.0089508
PMCID: PMC3934901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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