Genotyping and phenotyping cytochrome P450: perspectives for cancer treatment.

Abstract excerpt

As most anticancer agents display a narrow therapeutic window, patients may be susceptible to (extreme) toxicities or a lowered therapeutic outcome if not dosed adequately. Therefore, it is important to study factors which affect the pharmacokinetics and pharmacodynamics of these drugs. Among these, the contribution of genetic variation in drug metabolizing enzymes on the metabolism of anticancer agents has...

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