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Article

Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight.

The Journal of clinical investigation - 1 Dec 2005

Rosenbaum Michael, Goldsmith Rochelle, Bloomfield Daniel, Magnano Anthony, Weimer Louis, Heymsfield Steven, Gallagher Dympna, Mayer Laurel, Murphy Ellen, Leibel Rudolph L

Abstract excerpt

Maintenance of a reduced body weight is accompanied by decreased energy expenditure that is due largely to increased skeletal muscle work efficiency. In addition, decreased sympathetic nervous system tone and circulating concentrations of leptin, thyroxine, and triiodothyronine act coordinately to favor weight regain. These "weight-reduced" phenotypes are similar to those of leptin-deficient humans and rodents....

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Source

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Identifiers

PMID: 16322796
DOI: 10.1172/JCI25977
PMCID: PMC1297250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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