Article
The effect of a leptin phenotype on weight change and energy expenditure responses to acute and prolonged energetic stressors.
American journal of physiology. Endocrinology and metabolism - 1 Apr 2025
Falkenhain Kaja, Cabeza De Baca Tomás, Stinson Emma J, Ravussin Eric, Piaggi Paolo, Krakoff Jonathan, Redman Leanne M
Abstract excerpt
Leptin is a hormone produced by adipocytes that plays a crucial role in regulating energy homeostasis and body mass. Despite its close correlation with body fat, up to ∼40% of variation in plasma leptin concentration remains unexplained, allowing for the classification of a distinct "leptin phenotype." This leptin phenotype-characterized by either relatively high or relatively low leptin concentration relative to...
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