Article
Adiposity signaling and biological defense against weight gain: absence of protection or central hormone resistance?
The Journal of clinical endocrinology and metabolism - 1 Dec 2004
Schwartz Michael W, Niswender Kevin D
Abstract excerpt
An abundant and compelling literature supports the existence of a homeostatic system that dynamically adjusts energy intake and energy expenditure to promote stability of body fat mass. In the context of this system, the ease with which many individuals gain weight is difficult to explain. Some have argued that energy homeostasis operates primarily to defend against weight loss and that, over the course of...
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