Article
Surface antigen expression and correlation with variable heavy-chain gene mutation status in chronic lymphocytic leukemia.
European journal of haematology - 1 Jan 2003
Vilpo Juhani, Tobin Gerard, Hulkkonen Janne, Hurme Mikko, Thunberg Ulf, Sundström Christer, Vilpo Leena, Rosenquist Richard
Abstract excerpt
Recent studies have demonstrated that B-cell chronic lymphocytic leukemia (CLL) consists of two clinical entities with either somatically hypermutated (M-CLL) or unmutated (UM-CLL) immunoglobulin variable heavy-chain (VH) regions. In view of the fact that the cellular biology of these two subsets of disease is currently unexplored, we performed an extensive analysis of the surface antigen expression and...
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