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Article

No mutations but an increased frequency of SDHx polymorphisms in patients with sporadic and familial medullary thyroid carcinoma.

Endocrine-related cancer - 1 Dec 2005

Montani M, Schmitt A M, Schmid S, Locher T, Saremaslani P, Heitz P U, Komminoth P, Perren A

Abstract excerpt

Germline mutations of the three succinate dehydrogenase subunits SDHB, SDHC and SDHD have recently been associated with familial pheochromocytoma and paraganglioma. Several reasons make these genes candidate tumor suppressor genes for medullary thyroid carcinoma (MTC): (1) SDHB lies on chromosome 1p, the region known to be deleted most frequently in MTC, (2) MTCs develop from neural crest-derived cells, as do...

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Source

Identifiers

PMID: 16322339
DOI: 10.1677/erc.1.00996

Genes

SDHB
SDHD
SDHC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

No mutations but an increased frequency of SDHx polymorphisms in patients with sporadic and familial medullary thyroid carcinoma.PMID 16322339Read ↗

Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytomaSemantic proximity Read ↗

Investigation of the role of SDHB inactivation in sporadic phaeochromocytoma and neuroblastoma.Semantic proximity Read ↗

Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis.Semantic proximity Read ↗

Succinate dehydrogenase D variants do not constitute a risk factor for developing C cell hyperplasia or sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

SDHA immunohistochemistry detects germline SDHA gene mutations in apparently sporadic paragangliomas and pheochromocytomas.Semantic proximity Read ↗

Absence of somatic SDHD mutations in sporadic neuroendocrine tumors and detection of two germline variants in paraganglioma patients.Semantic proximity Read ↗

Mutations and polymorphisms in the SDHB, SDHD, VHL, and RET genes in sporadic and familial pheochromocytomas.Semantic proximity Read ↗

The first Dutch SDHB founder deletion in paraganglioma-pheochromocytoma patients.Semantic proximity Read ↗

W43X SDHD mutation in sporadic head and neck paraganglioma.Semantic proximity Read ↗

Reduced expression and loss of heterozygosity of the SDHD gene in colorectal and gastric cancerSemantic proximity Read ↗

Active succinate dehydrogenase (SDH) and lack of SDHD mutations in sporadic paragangliomas.Semantic proximity Read ↗

Functional consequences of a SDHB gene mutation in an apparently sporadic pheochromocytoma.Semantic proximity Read ↗

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