Article
Mutations and polymorphisms in the SDHB, SDHD, VHL, and RET genes in sporadic and familial pheochromocytomas.
Endocrine - 1 Jun 2009
Waldmann Jens, Langer Peter, Habbe Nils, Fendrich Volker, Ramaswamy Anette, Rothmund Matthias, Bartsch Detlef K, Slater Emily P
Abstract excerpt
The prevalence of germ line mutations within the RET-protooncogene and the tumor suppressor genes SDHB, SDHD, and VHL in pheochromocytomas (PC) varies in recent studies from 12 to 24%, if one look at them collectively. DNA was extracted from frozen tumor tissue as well as from blood leukocytes of 36 PC (26 sporadic/10 MEN2). Exons 1-8 of the SDHB-gene, 1-4 of the SDHD-gene, 1-3 of the VHL-gene, and exons 10, 11,...
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