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Article

Investigation of the role of SDHB inactivation in sporadic phaeochromocytoma and neuroblastoma.

British journal of cancer - 15 Nov 2004

Astuti D, Morris M, Krona C, Abel F, Gentle D, Martinsson T, Kogner P, Neumann H P H, Voutilainen R, Eng C, Rustin P, Latif F, Maher E R

Abstract excerpt

Germline mutations in the succinate dehydrogenase (SDH) (mitochondrial respiratory chain complex II) subunit B gene, SDHB, cause susceptibility to head and neck paraganglioma and phaeochromocytoma. Previously, we did not identify somatic SDHB mutations in sporadic phaeochromocytoma, but SDHB maps to 1p36, a region of frequent loss of heterozygosity (LOH) in neuroblastoma as well. Hence, to evaluate SDHB as a...

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Source

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Identifiers

PMID: 15505628
DOI: 10.1038/sj.bjc.6602202
PMCID: PMC2410049

Genes

SDHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigation of the role of SDHB inactivation in sporadic phaeochromocytoma and neuroblastoma.PMID 15505628Read ↗

Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomasSemantic proximity Read ↗

Active succinate dehydrogenase (SDH) and lack of SDHD mutations in sporadic paragangliomas.Semantic proximity Read ↗

No evidence for involvement of SDHD in neuroblastoma pathogenesis.Semantic proximity Read ↗

Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytomaSemantic proximity Read ↗

Analysis of the SDHD gene, the susceptibility gene for familial paraganglioma syndrome (PGL1), in pheochromocytomas.Semantic proximity Read ↗

Methylation-associated PHOX2B gene silencing is a rare event in human neuroblastoma.Semantic proximity Read ↗

Genetic analysis of mitochondrial complex II subunits SDHD, SDHB and SDHC in paraganglioma and phaeochromocytoma susceptibility.Semantic proximity Read ↗

The occurrence of SDHB gene mutations in pheochromocytoma.Semantic proximity Read ↗

No mutations but an increased frequency of SDHx polymorphisms in patients with sporadic and familial medullary thyroid carcinoma.Semantic proximity Read ↗

Potential Pitfalls of SDH Immunohistochemical Detection in Paragangliomas and Phaeochromocytomas Harbouring Germline SDHx Gene MutationSemantic proximity Read ↗

RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma tumours.Semantic proximity Read ↗

Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma.Semantic proximity Read ↗

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