Article
Succinate dehydrogenase D variants do not constitute a risk factor for developing C cell hyperplasia or sporadic medullary thyroid carcinoma.
The Journal of clinical endocrinology and metabolism - 1 Apr 2005
Cascon Alberto, Cebrian Arancha, Pollan Marina, Ruiz-Llorente Sergio, Montero-Conde Cristina, Leton Rocio, Gutierrez Ruth, Lesueur Fabienne, Milne Roger L, Gonzalez-Albarran Olga, Lucas-Morante Tomas, Benitez Javier, Ponder Bruce A J, Robledo Mercedes
Abstract excerpt
Medullary thyroid carcinoma (MTC) is a tumor that arises from parafollicular cells of the thyroid gland. MTC can occur sporadically (75%) or as part of inherited cancer syndromes (25%). In most cases, hereditary MTC evolves from preneoplastic C cell hyperplasia (CCH), so early detection of this pathology would evidently be critical. A recent study reports that alterations in succinate dehydrogenase (SDH) D are...
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