Article
Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis.
European journal of endocrinology - 1 Jan 2014
Papathomas Thomas G, Gaal Jose, Corssmit Eleonora P M, Oudijk Lindsey, Korpershoek Esther, Heimdal Ketil, Bayley Jean-Pierre, Morreau Hans, van Dooren Marieke, Papaspyrou Konstantinos, Schreiner Thomas, Hansen Torsten, Andresen Per Arne, Restuccia David F, van Kessel Ingrid, van Leenders Geert J L H, Kros Johan M, Looijenga Leendert H J, Hofland Leo J, Mann Wolf, van Nederveen Francien H, Mete Ozgur, Asa Sylvia L, de Krijger Ronald R, Dinjens Winand N M
Abstract excerpt
OBJECTIVE: Although the succinate dehydrogenase (SDH)-related tumor spectrum has been recently expanded, there are only rare reports of non-pheochromocytoma/paraganglioma tumors in SDHx-mutated patients. Therefore, questions still remain unresolved concerning the aforementioned tumors with regard to their pathogenesis, clinicopathological phenotype, and even causal relatedness to SDHx mutations. Absence of SDHB...
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