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Article

Reduced expression and loss of heterozygosity of the SDHD gene in colorectal and gastric cancer

1 Sept 2003

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations occur in a variety of human cancers, suggesting a possible role for mitochondrial respiratory functions in tumorigenesis. Recent studies have demonstrated that SDHD, a nuclear gene encoding one of the mitochondrial complex II subunits, acts as a tumor-suppressor for hereditary paragangliomas and pheochromocytomas. In order to determine whether the SDHD function plays a wider...

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PMID: 12883710
DOI: 10.3892/or.10.5.1375

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Related research

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Reduced expression and loss of heterozygosity of the SDHD gene in colorectal and gastric cancerPMID 12883710Read ↗

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The SDHD:p.H102R Variant Is Frequent in Russian Patients with Head and Neck Paragangliomas and Associated with Loss of 11p15.5 Region and Hypermethylation of H19-DMR.Semantic proximity Read ↗

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W43X SDHD mutation in sporadic head and neck paraganglioma.Semantic proximity Read ↗

Disomy as the genetic underlying mechanisms of loss of heterozigosity in SDHD-paragangliomas.Semantic proximity Read ↗

Predominant expression of mutated allele of the succunate dehydrogenase D (SDHD) gene in the SDHD-related paragangliomas.Semantic proximity Read ↗

Nearly all hereditary paragangliomas in the Netherlands are caused by two founder mutations in the SDHD gene.Semantic proximity Read ↗

A novel G106D alteration of the SDHD gene in a pedigree with familial paraganglioma.Semantic proximity Read ↗

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