Article
In yeast, loss of Hog1 leads to osmosensitivity of autophagy.
The Biochemical journal - 15 Feb 2006
Prick Tanja, Thumm Michael, Köhrer Karl, Häussinger Dieter, Vom Dahl Stephan
Abstract excerpt
In mammalian liver, proteolysis is regulated by the cellular hydration state in a microtubule- and p38(MAPK) (p38 mitogen-activated protein kinase)-dependent fashion. Osmosensing in liver cells towards proteolysis is achieved by activation of integrin receptors. The yeast orthologue of p38(MAPK) is Hog1 (high-osmolarity glycerol 1), which is involved in the hyperosmotic-response pathway. Since it is not known...
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