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Article

FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores.

PLoS genetics - 1 Oct 2015

Possik Elite, Ajisebutu Andrew, Manteghi Sanaz, Gingras Marie-Claude, Vijayaraghavan Tarika, Flamand Mathieu, Coull Barry, Schmeisser Kathrin, Duchaine Thomas, van Steensel Maurice, Hall David H, Pause Arnim

Abstract excerpt

Mechanisms of adaptation to environmental changes in osmolarity are fundamental for cellular and organismal survival. Here we identify a novel osmotic stress resistance pathway in Caenorhabditis elegans (C. elegans), which is dependent on the metabolic master regulator 5'-AMP-activated protein kinase (AMPK) and its negative regulator Folliculin (FLCN). FLCN-1 is the nematode ortholog of the tumor suppressor FLCN,...

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Identifiers

PMID: 26439621
DOI: 10.1371/journal.pgen.1005520
PMCID: PMC4595296

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FLCN

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