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Article

Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis.

PloS one - 19 Apr 2011

Altomare Deborah A, Menges Craig W, Xu Jinfei, Pei Jianming, Zhang Lili, Tadevosyan Ara, Neumann-Domer Erin, Liu Zemin, Carbone Michele, Chudoba Ilse, Klein-Szanto Andres J, Testa Joseph R

Abstract excerpt

The CDKN2A/ARF locus encompasses overlapping tumor suppressor genes p16(INK4A) and p14(ARF), which are frequently co-deleted in human malignant mesothelioma (MM). The importance of p16(INK4A) loss in human cancer is well established, but the relative significance of p14(ARF) loss has been debated. The tumor predisposition of mice singly deficient for either Ink4a or Arf, due to targeting of exons 1α or 1β,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

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Source

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Identifiers

PMID: 21526190
DOI: 10.1371/journal.pone.0018828
PMCID: PMC3079727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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