Article
Genotypic and allelic frequencies of SULT1A1 polymorphisms in women receiving adjuvant tamoxifen therapy.
Breast cancer research and treatment - 1 Jan 2006
Grabinski J L, Smith L S, Chisholm G B, Drengler R, Rodriguez G I, Lang A S, Kalter S P, Garner A M, Fichtel L M, Hollsten J, Pollock B H, Kuhn J G
Abstract excerpt
Human sulfotransferase 1A1 (SULT1A1) is involved in the metabolism of a number of substances including 4-hydroxytamoxifen. It has been shown that patients who are homozygous for the variant SULT1A1 *2/*2 have lower catalytic activity. Previous data has suggested that patients with this particular genotype may be at a greater risk of developing breast cancer or not responding to tamoxifen therapy. To date, there...
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