Article
Associations between polymorphisms in glucuronidation and sulfation enzymes and sex steroid concentrations in premenopausal women in the United States.
The Journal of steroid biochemistry and molecular biology - 1 Mar 2011
Yong Mellissa, Schwartz Stephen M, Atkinson Charlotte, Makar Karen W, Thomas Sushma S, Stanczyk Frank Z, Westerlind Kim C, Newton Katherine M, Holt Victoria L, Leisenring Wendy M, Lampe Johanna W
Abstract excerpt
Glucuronidation, catalyzed by UDP-glucuronosyltransferases (UGT) and sulfation, catalyzed by sulfotransferases (SULT), are pathways through which sex steroids are metabolized to less active compounds. These enzymes are highly polymorphic and genetic variants frequently result in higher or lower activity. The phenotypic effects of these polymorphisms on circulating sex steroids in premenopausal women have not yet...
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