Article
Sulfotransferase 1A1 genotype as a potential modifier of breast cancer risk among premenopausal women.
Pharmacogenetics and genomics - 1 Oct 2005
Sillanpää Pia, Kataja Vesa, Eskelinen Matti, Kosma Veli-Matti, Uusitupa Matti, Vainio Harri, Mitrunen Katja, Hirvonen Ari
Abstract excerpt
SULT1A1 is involved in biotransformation of many endogenous and exogenous substrates, such as drugs, hormones and tobacco smoke carcinogens. A polymorphism in the sulfotransferase 1A1 gene (SULT1A1) results in an amino acid change from Arg to His at codon 213. The His allele (SULT1A1*2) has been shown to encode a protein with much lower catalytic activity than the protein encoded by the Arg allele (SULT1A1*1). We...
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