Polymorphisms in CYP2A13 and UGT1A7 genes and head and neck cancer susceptibility in North Indians.

doi:10.1111/j.1601-0825.2010.01683.x

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Polymorphisms in CYP2A13 and UGT1A7 genes and head and neck cancer susceptibility in North Indians.

Oral diseases - 1 Nov 2010

Sharma R, Ahuja M, Panda Nk, Khullar M

Abstract excerpt

OBJECTIVES: To examine role of genetic variants of CYP2A13 and UGT1A7 genes, involved in activation and detoxification of tobacco carcinogens, with risk of head and neck cancer as well as to assess the potential modifying role of gene-gene and gene-environment interactions. METHODS: 203 head and neck cancer patients and 201 healthy controls were genotyped for functional polymorphisms of CYP2A13 and UGT1A7 genes...

Topics

Alcohol Drinking
Aryl Hydrocarbon Hydroxylases
Carcinogens
Chromatography, High Pressure Liquid
Codon
Cohort Studies
Cytosine
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Glucuronosyltransferase

Haplotypes

Head and Neck Neoplasms

Heterozygote

Humans

India

Source

Open in PubMed

Identifiers

PMID: 20534012
DOI: 10.1111/j.1601-0825.2010.01683.x

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