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Article

Collapsed State Mediates the Low Fidelity of the DNA Polymerase β I260 Mutant.

Biochemistry - 1 Oct 2024

Fijen Carel, Chavira Cristian, Alnajjar Khadijeh, Sawyer Danielle L, Sweasy Joann B

Abstract excerpt

DNA polymerase β (Pol β) fills single nucleotide gaps during base excision repair. Deficiencies in Pol β can lead to increased mutagenesis and genomic instability in the cell, resulting in cancer. Our laboratory has previously shown that the I260 M somatic mutation of Pol β, which was first identified in prostate cancer, has reduced nucleotide discrimination in a sequence context-dependent manner. I260 M...

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Identifiers

PMID: 39299701
DOI: 10.1021/acs.biochem.4c00263
PMCID: PMC11448664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Collapsed State Mediates the Low Fidelity of the DNA Polymerase β I260 Mutant.PMID 39299701Read ↗

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Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator.Semantic proximity Read ↗

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