Article
Molecular and synaptic changes in the hippocampus underlying superior spatial abilities in pre-symptomatic G93A+/+ mice overexpressing the human Cu/Zn superoxide dismutase (Gly93 --> ALA) mutation.
Experimental neurology - 1 Feb 2006
Spalloni Alida, Geracitano Raffaella, Berretta Nicola, Sgobio Carmelo, Bernardi Giorgio, Mercuri Nicola B, Longone Patrizia, Ammassari-Teule Martine
Abstract excerpt
Although amyotrophic lateral sclerosis (ALS) is mainly considered as a motor disease, extramotor neural and cognitive alterations have also been reported in ALS patients. There is evidence that mutations in the Cu/Zn superoxide dismutase (SOD1) gene are implicated in about 20% of familiar ALS and transgenic mice overexpressing the human Cu/Zn superoxide dismutase (GLY(93) --> ALA) mutation show an ALS-like...
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