Article
Abnormal medial prefrontal cortex connectivity and defective fear extinction in the presymptomatic G93A SOD1 mouse model of ALS.
Genes, brain, and behavior - 1 Jun 2008
Sgobio C, Trabalza A, Spalloni A, Zona C, Carunchio I, Longone P, Ammassari-Teule M
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a fatal progressive neuropathy associated with the degeneration of spinal and brainstem motor neurons. Although ALS is essentially considered as a lower motor neuron disease, prefrontal cortex atrophy underlying executive function deficits have been extensively reported in ALS patients. Here, we examine whether prefrontal cortex neuronal abnormalities and related cognitive...
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