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Article

Altered long-term corticostriatal synaptic plasticity in transgenic mice overexpressing human CU/ZN superoxide dismutase (GLY(93)-->ALA) mutation.

Neuroscience - 1 Jan 2003

Geracitano R, Paolucci E, Prisco S, Guatteo E, Zona C, Longone P, Ammassari-Teule M, Bernardi G, Berretta N, Mercuri N B

Abstract excerpt

Apart from the extensive loss of motor neurons, degeneration of midbrain dopaminergic cells has been described in both familial and sporadic forms of amyotrophic lateral sclerosis (ALS). Mice overexpressing the mutant human Cu/Zn superoxide dismutase (SOD1) show an ALS-like phenotype in that they show a progressive death of motor neurons accompanied by degeneration of dopaminergic cells. To describe the...

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Identifiers

PMID: 12699776
DOI: 10.1016/s0306-4522(02)00809-6

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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