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Article

Quantitative motor assessment in FALS mice

1 Sept 1997

Abstract excerpt

We have evaluated the G1H line of transgenic mice overexpressing a familial ALS mutation of SOD1 (Gly-93-->Ala) in tasks assessing different aspects of motor function to determine how early these deficits could be detected and their order of appearance. The earliest deficits were observed in tests of muscle strength and coordination as early as 8 weeks of age and their development appeared to be biphasic, whereas...

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PMID: 9376520
DOI: 10.1097/00001756-199709080-00012

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