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Article

Maladaptive exploratory behavior and neuropathology of the PS-1 P117L Alzheimer transgenic mice.

Brain research bulletin - 1 May 2013

Zufferey Valérie, Vallet Philippe G, Moeri Michaël, Moulin-Sallanon Marcelle, Piotton Françoise, Marin Pascale, Savioz Armand

Abstract excerpt

Patients with the early-onset Alzheimer's disease P117L mutation in the presenilin-1 gene (PS-1) present pathological hallmarks in the hippocampus, the frontal cortex and the basal ganglia. In the present work we determined by immunohistochemistry which brain regions were injured in the transgenic PS-1 P117L mice, in comparison to their littermates, the B6D2 mice. Furthermore, as these regions are involved in...

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Identifiers

PMID: 23396115
DOI: 10.1016/j.brainresbull.2013.01.011

Genes

PSD

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