Article
Allele-sharing models: LOD scores and accurate linkage tests.
American journal of human genetics - 1 Nov 1997
Kong A, Cox N J
Abstract excerpt
Starting with a test statistic for linkage analysis based on allele sharing, we propose an associated one-parameter model. Under general missing-data patterns, this model allows exact calculation of likelihood ratios and LOD scores and has been implemented by a simple modification of existing software. Most important, accurate linkage tests can be performed. Using an example, we show that some previously...
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