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Article

Mutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and causes a variable small-eye phenotype.

Investigative ophthalmology & visual science - 1 Apr 2008

Puk Oliver, Löster Jana, Dalke Claudia, Soewarto Dian, Fuchs Helmut, Budde Birgit, Nürnberg Peter, Wolf Eckhard, de Angelis Martin Hrabé, Graw Jochen

Abstract excerpt

PURPOSE: The purpose of the study was the characterization of the novel small-eye mutant Aey12 in the mouse. METHODS: The eyes of the mutants were described morphologically and histologically and by in situ hybridization. RESULTS: The homozygotes were viable and fully fertile, which identifies Aey12 as a new microphthalmia phenotype in the mouse, different from Maf or Pax6 mutants. Histologic analysis indicated...

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PMID: 18385072
DOI: 10.1167/iovs.07-1033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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