Article
Ethylnitrosourea-induced mutation in mice leads to the expression of a novel protein in the eye and to dominant cataracts.
Genetics - 1 Mar 2001
Graw J, Klopp N, Löster J, Soewarto D, Fuchs H, Becker-Follmann J, Reis A, Wolf E, Balling R, Habré de Angelis M
Abstract excerpt
A novel ENU-induced mutation in the mouse leading to a nuclear and zonular opacity of the eye lens (Aey1) was mapped to chromosome 1 between the markers D1Mit303 and D1Mit332. On the basis of the chromosomal position, the gamma-crystallin encoding gene cluster (Cryg) and the betaA2-crystallin encoding gene Cryba2 were tested as candidate genes. An A --> T mutation destroys the start codon of the Cryge gene in the...
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