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A new Fgf10 mutation in the mouse leads to atrophy of the harderian gland and slit-eye phenotype in heterozygotes: a novel model for dry-eye disease?

Investigative ophthalmology & visual science - 1 Sept 2009

Puk Oliver, Esposito Irene, Söker Torben, Löster Jana, Budde Birgit, Nürnberg Peter, Michel-Soewarto Dian, Fuchs Helmut, Wolf Eckhard, Hrabé de Angelis Martin, Graw Jochen

Abstract excerpt

PURPOSE: The purpose of the present study was to characterize a new slit-eye phenotype in the mouse. METHODS: Genomewide linkage analysis was performed, and a candidate gene was sequenced. Eyes of the mutants were described morphologically, histologically, and by in situ hybridization. To allow morphologic and functional studies of the retina, mutants were outcrossed to C57BL/6. RESULTS: Within an ongoing...

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Identifiers

PMID: 19407009
DOI: 10.1167/iovs.09-3451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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