Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression.

The Journal of biological chemistry - 27 Jan 2006

Hu Kebin, Yang Junwei, Tanaka Sakae, Gonias Steven L, Mars Wendy M, Liu Youhua

Abstract excerpt

Tissue-type plasminogen activator (tPA), a serine protease well known for generating plasmin, has been demonstrated to induce matrix metalloproteinase-9 (MMP-9) gene expression and protein secretion in renal interstitial fibroblasts. However, exactly how tPA transduces its signal into the nucleus to control gene expression is unknown. This study investigated the mechanism by which tPA induces MMP-9 gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fluorescent Antibody Technique, Indirect
Share to Gelatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Low Density Lipoprotein Receptor-Related Protein-1

Share to MAP Kinase Kinase 1

Share to Matrix Metalloproteinase 9

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Tissue Plasminogen Activator

Source

Identifiers

PMID: 16303771
DOI: 10.1074/jbc.M504988200

Genes

NRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression.PMID 16303771Read ↗

The p38 SAPK pathway regulates the expression of the MMP-9 collagenase via AP-1-dependent promoter activation.Semantic proximity Read ↗

Emerging Features in the Regulation of MMP-9 Gene Expression for the Development of Novel Molecular Targets and Therapeutic StrategiesSemantic proximity Read ↗

Signal transduction and cell‐type specific regulation of matrix metalloproteinase gene expression: Can MMPs be good for you?Semantic proximity Read ↗

Tissue plasminogen activator promotes postischemic neutrophil recruitment via its proteolytic and nonproteolytic properties.Semantic proximity Read ↗

Transforming growth factor-β1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytesSemantic proximity Read ↗

Regulation of MMP-9 gene expression for the development of novel molecular targets against cancer and inflammatory diseasesSemantic proximity Read ↗

Protein tyrosine kinase and p38 MAP kinase pathways are involved in stimulation of matrix metalloproteinase-9 by TNF-alpha in human monocytes.Semantic proximity Read ↗

Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblastsSemantic proximity Read ↗

From Plasminogen to Plasmin: Role of Plasminogen Receptors in Human CancerSemantic proximity Read ↗

Human tissue-type plasminogen activator.Semantic proximity Read ↗

Leukocyte-derived MMP9 is crucial for the recruitment of proinflammatory macrophages in experimental glomerulonephritis.Semantic proximity Read ↗

Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.