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Regulation of MMP-9 gene expression for the development of novel molecular targets against cancer and inflammatory diseases

1 Oct 2004

Abstract excerpt

The need to pharmacologically control the proteolytic activity of matrix metalloproteinases (MMPs) has been commonly acknowledged, despite its limited efficacy in clinical trials. Among the reasons that explain this failure is our limited understanding of the signals that control the expression of MMPs in different cell types during different pathological conditions. Thus, future therapies must rely on more...

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PMID: 15469396
DOI: 10.1517/14728222.8.5.473

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