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Article

Tissue plasminogen activator promotes postischemic neutrophil recruitment via its proteolytic and nonproteolytic properties.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2014

Uhl Bernd, Zuchtriegel Gabriele, Puhr-Westerheide Daniel, Praetner Marc, Rehberg Markus, Fabritius Matthias, Hessenauer Maximilian, Holzer Martin, Khandoga Andrej, Fürst Robert, Zahler Stefan, Krombach Fritz, Reichel Christoph A

Abstract excerpt

OBJECTIVE: Neutrophil infiltration of the postischemic tissue considerably contributes to organ dysfunction on ischemia/reperfusion injury. Beyond its established role in fibrinolysis, tissue-type plasminogen activator (tPA) has recently been implicated in nonfibrinolytic processes. The role of this serine protease in the recruitment process of neutrophils remains largely obscure. APPROACH AND RESULTS: Using in...

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PMID: 24764453
DOI: 10.1161/ATVBAHA.114.303721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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