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Article

Expression of Cataract-linked γ-Crystallin Variants in Zebrafish Reveals a Proteostasis Network That Senses Protein Stability.

The Journal of biological chemistry - 2 Dec 2016

Wu Shu-Yu, Zou Ping, Fuller Alexandra W, Mishra Sanjay, Wang Zhen, Schey Kevin L, Mchaourab Hassane S

Abstract excerpt

The refractivity and transparency of the ocular lens is dependent on the stability and solubility of the crystallins in the fiber cells. A number of mutations of lens crystallins have been associated with dominant cataracts in humans and mice. Of particular interest were γB- and γD-crystallin mutants linked to dominant cataracts in mouse models. Although thermodynamically destabilized and aggregation-prone, these...

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Identifiers

PMID: 27770023
DOI: 10.1074/jbc.M116.749606
PMCID: PMC5207241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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