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Article

Altered chaperone-like activity of alpha-crystallins promotes cataractogenesis.

The Journal of biological chemistry - 24 Dec 2010

Cheng Catherine, Xia Chun-hong, Huang Qingling, Ding Linlin, Horwitz Joseph, Gong Xiaohua

Abstract excerpt

Despite the enormous number of studies demonstrating changes in the chaperone-like activity of α-crystallins in vitro, little is known about how these changes influence life-long lens transparency in vivo. Using the γB-crystallin I4F mutant protein as a target for αA-crystallins, we examined how...

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Identifiers

PMID: 20959464
DOI: 10.1074/jbc.M110.154534
PMCID: PMC3003416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20959464-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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