Article
Allelotyping analysis at chromosome 13q of high-grade prostatic intraepithelial neoplasia and clinically insignificant and significant prostate cancers.
The Prostate - 1 Mar 2006
Lu Wei, Takahashi Hiroyuki, Furusato Masakuni, Maekawa Suguru, Nakano Masataka, Meng Chenxi, Kikuchi Yasushi, Sudo Akemi, Hano Hiroshi
Abstract excerpt
BACKGROUND: Loss of heterozygosity (LOH) at 13q is one of the most common chromosomal alterations in high-stage prostate cancer, yet little is known about genetic changes in earlier-stage prostate cancer. METHODS: We used five microsatellite markers at 13q14, 21, and 33 to compare LOH frequencies in 51 lesions of high-grade prostatic intraepithelial neoplasia (HGPIN), 21 cases of incidental prostate cancers...
Topics
- Alleles
- Cell Transformation, Neoplastic
- Chromosomes, Human, Pair 13
- Humans
- Loss of Heterozygosity
- Male
- Microsatellite Repeats
- Neoplasm Metastasis
- Polymerase Chain Reaction
- Prostatic Intraepithelial Neoplasia
- Prostatic Neoplasms