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Article

Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection.

Hepatology (Baltimore, Md.) - 1 Jun 2008

Neumann-Haefelin Christoph, Timm Jörg, Spangenberg Hans Christian, Wischniowski Natalie, Nazarova Natalja, Kersting Nadine, Roggendorf Michael, Allen Todd M, Blum Hubert E, Thimme Robert

Abstract excerpt

UNLABELLED: Virus-specific CD8+ T-cells play an important role in the outcome of acute hepatitis C virus (HCV) infection. In the chronic phase, however, HCV can persist despite the presence of virus-specific T-cell responses. Therefore, we set out to perform a full-breadth analysis of the intrahepatic virus-specific CD8+ T-cell response, its relation to the peripheral T-cell response, and the overall influence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18454507
DOI: 10.1002/hep.22242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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