Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lidocaine attenuation testing: An in vivo investigation of putative LQT3-associated variants in the SCN5A-encoded sodium channel.

Heart rhythm - 1 Aug 2017

Anderson Heather N, Bos J Martijn, Kapplinger Jamie D, Meskill Jana M, Ye Dan, Ackerman Michael J

Abstract excerpt

BACKGROUND: Long QT syndrome type 3 (LQT3) accounts for 5%-10% of long QT syndrome and results from gain-of-function mutations in the SCN5A-encoded sodium channel. Approximately 2% of healthy individuals host rare SCN5A variants of uncertain significance (VUS). Distinction of true LQT3-causative mutations from background genetic noise is essential. OBJECTIVE: The purpose of this study was to assess the use of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Conduction System Disease
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrocardiography

Share to Heart Rate

Share to Long QT Syndrome

Share to NAV1.5 Voltage-Gated Sodium Channel

Share to Treatment Outcome

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 28412158
DOI: 10.1016/j.hrthm.2017.04.020
PMCID: PMC6590893

Genes

LAT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lidocaine attenuation testing: An in vivo investigation of putative LQT3-associated variants in the SCN5A-encoded sodium channel.PMID 28412158Read ↗

Long QT syndrome: biophysical and pharmacologic mechanisms in LQT3.Semantic proximity Read ↗

Combination of cardiac conduction disease and long QT syndrome caused by mutation T1620K in the cardiac sodium channel.Semantic proximity Read ↗

Mechanism of lidocaine block of late current in long Q-T mutant Na+ channels.Semantic proximity Read ↗

Mutations in cardiac sodium channels: clinical implications.Semantic proximity Read ↗

Phenotypic characterization of a novel long-QT syndrome mutation (R1623Q) in the cardiac sodium channel.Semantic proximity Read ↗

Lidocaine block of LQT-3 mutant human Na+ channels.Semantic proximity Read ↗

The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome.Semantic proximity Read ↗

A novel LQT3 mutation implicates the human cardiac sodium channel domain IVS6 in inactivation kinetics.Semantic proximity Read ↗

Lidocaine-induced Brugada syndrome phenotype linked to a novel double mutation in the cardiac sodium channel.Semantic proximity Read ↗

Trafficking defects and gating abnormalities of a novel SCN5A mutation question gene-specific therapy in long QT syndrome type 3.Semantic proximity Read ↗

A mutation in the sodium channel is responsible for the association of long QT syndrome and familial atrial fibrillation.Semantic proximity Read ↗

Revealing the Concealed Nature of Long-QT Type 3 Syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.