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Article

Lidocaine block of LQT-3 mutant human Na+ channels.

Circulation research - 1 Jul 1996

An R H, Bangalore R, Rosero S Z, Kass R S

Abstract excerpt

In transiently transfected mammalian cells we have identified pharmacological consequences of a naturally occurring deletion mutation, delta KPQ, of the human heart Na+ channel alpha subunit that previously has been linked to one form of the long QT syndrome, an inherited heart disease. Our results show that the Class IB antiarrhythmic agent lidocaine blocks maintained inward current through and slows recovery...

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Identifiers

PMID: 8925557
DOI: 10.1161/01.res.79.1.103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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