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Article

A paradoxical effect of lidocaine for the N406S mutation of SCN5A associated with Brugada syndrome.

International journal of cardiology - 18 Oct 2007

Itoh Hideki, Tsuji Keiko, Sakaguchi Tomoko, Nagaoka Iori, Oka Yuko, Nakazawa Yuko, Yao Takenori, Jo Hikari, Ashihara Takashi, Ito Makoto, Horie Minoru, Imoto Keiji

Abstract excerpt

BACKGROUND: Accelerated intermediate inactivation, which is caused by mutations in the cardiac voltage-gated sodium channel alpha-subunit gene (SCN5A), is one of the molecular mechanisms underlying Brugada syndrome. The N406S mutation associated with Brugada syndrome results in the accelerated in...

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Identifiers

PMID: 17445919
DOI: 10.1016/j.ijcard.2007.02.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17445919-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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