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Article

Three key residues underlie the differential affinity of the TGFbeta isoforms for the TGFbeta type II receptor.

Journal of molecular biology - 6 Jan 2006

De Crescenzo Gregory, Hinck Cynthia S, Shu Zhanyong, Zúñiga Jorge, Yang Junhua, Tang Yuping, Baardsnes Jason, Mendoza Valentín, Sun LuZhe, López-Casillas Fernando, O'Connor-McCourt Maureen, Hinck Andrew P

Abstract excerpt

TGFbeta1, beta2, and beta3 are 25kDa homodimeric polypeptides that play crucial non-overlapping roles in development, tumor suppression, and wound healing. They exhibit 70-82% sequence identity and transduce their signals by binding and bringing together the TGFbeta type I and type II receptors, TbetaRI and TbetaRII. TGFbeta2 differs from the other isoforms in that it binds TbetaRII weakly and is dependent upon...

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Identifiers

PMID: 16300789
DOI: 10.1016/j.jmb.2005.10.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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