Article

A novel splice variant of human TGF-β type II receptor encodes a soluble protein and its Fc-tagged version prevents liver fibrosis <i>in vivo</i>

2021-03-01

Abstract excerpt

We describe, for the first time, a new splice variant of the human TGF-β type II receptor (TβRII). The new transcript lacks 149 nucleotides, causing a frameshift with the appearance of an early stop codon, rendering a truncated mature protein of 57 amino acids. The predicted protein, lacking the transmembrane domain and with a distinctive 13 amino acid stretch in the C-terminus, was named TβRII-Soluble Endogenous...

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Literature Corpus work: 9e04e0dd-f432-5098-b3ea-8806b4a5333d
DOI: 10.1101/2021.03.01.433173

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