Article

Recurrent evolution of ligand-binding domain multiplicity fine-tunes TGFβ signaling in vertebrates

2026-01-16

Abstract excerpt

<title>Abstract</title> <p>From sponges to mammals, TGFβ-signaling has evolved as one of the key pathways governing body plans, organ and cell type differentiations as well as homeostatic balance. The extensive conservation of the receptor core architecture across metazoans reflects strong evolutionary constraints, consistent with the severe developmental phenotypes caused by TGFβ receptor mutations in humans. He...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bb7266b5-69b2-5008-9f93-f15597ac4ad3
DOI: 10.21203/rs.3.rs-8406929/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Recurrent evolution of ligand-binding domain multiplicity fine-tunes TGFβ signaling in vertebratesDOI 10.21203/rs.3.rs-8406929/v1Read

Decoding clinical diversity in monogenic TGFBR1 and TGFBR2 mutations: insights into the interplay of molecular mechanisms and hypomorphicitySemantic proximity Read

Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor BindingSemantic proximity Read

Molecular evolution of a developmental pathway: phylogenetic analyses of transforming growth factor-beta family ligands, receptors and Smad signal transducers.Semantic proximity Read

TGFβ family signaling: novel insights in development and diseaseSemantic proximity Read

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF‐β receptorsSemantic proximity Read

Molecular Characterization of TGF-Beta Gene Family in Buffalo to Identify Gene Duplication and Functional Mutations.Semantic proximity Read

Recent advances in understanding contextual TGFβ signalingSemantic proximity Read

Genomics of the TGF-beta subfamily in CancerSemantic proximity Read

TGFβ Signaling: Receptors, Transducers, and Mad ProteinsSemantic proximity Read

Receptors for the TGF-β familySemantic proximity Read

The type II TGF-beta receptor signals diverse responses in cooperation with the type I receptor.Semantic proximity Read

Origin and Molecular Evolution of Receptor Tyrosine Kinases with Immunoglobulin-Like DomainsSemantic proximity Read