Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In-silico prediction of TGF-β1 non-synonymous variants and their impact on binding affinity to Fresolimumab.

Journal of biomolecular structure & dynamics - 1 Jan 2024

Ramzan Ammara, Yousaf Muhammad Abrar, Rashid Muhammad Usman, Basheera Shefin, Malkani Naila

Abstract excerpt

TGF-β1 is a potent immunoregulatory cytokine that plays diverse roles in development, bone healing, fibrosis, and cancer. However, characterizing TGF-β1 gene variants is challenging because the structural and functional consequences of these variants are still undetermined. In this study, we aimed to perform an in-silico analysis of TGF-β1 non-synonymous variants and their pathogenic effects on the TGF-β1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal, Humanized
Share to Binding Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Computer Simulation

Share to Molecular Docking Simulation

Share to Molecular Dynamics Simulation

Share to Polymorphism, Single Nucleotide

Share to Protein Binding

Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 37817532
DOI: 10.1080/07391102.2023.2268198

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In-silico prediction of TGF-β1 non-synonymous variants and their impact on binding affinity to Fresolimumab.PMID 37817532Read ↗

Structural impact, ligand-protein interactions, and molecular phenotypic effects of TGF-β1 gene variants: In silico analysis with implications for idiopathic pulmonary fibrosis.Semantic proximity Read ↗

Molecular insights into TGF-B signalling pathway disruption by non-synonymous SNPs variants in COPD: an in silico and molecular dynamics simulation study.Semantic proximity Read ↗

Functional nonsynonymous single nucleotide polymorphisms from the TGF-beta protein interaction network.Semantic proximity Read ↗

TGF-β1 functional polymorphisms: a review.Semantic proximity Read ↗

Analysis of consequences of non-synonymous SNP in feed conversion ratio associated TGF-β receptor type 3 gene in chickenSemantic proximity Read ↗

Genomics of the TGF-beta subfamily in CancerSemantic proximity Read ↗

Mutation update:TGFBIpathogenic and likely pathogenic variants in corneal dystrophiesSemantic proximity Read ↗

Genetic screening of TGFBI in Iranian patients with TGFBI-associated corneal dystrophies and a meta-analysis of global variation frequencies.Semantic proximity Read ↗

An Integrative Approach to Lung Cancer Therapy: Linking the TGF-β (+869 C/T) Polymorphism to a Structurally Validated Natural Inhibitor.Semantic proximity Read ↗

A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-beta1 (TGF-beta1) and its signaling pathway.Semantic proximity Read ↗

In silico analysis of the potential effects of the disease-associated point mutations on the kinase activity of TGFBR1 and TGFBR2 receptorsSemantic proximity Read ↗

Prediction of the most deleterious non-synonymous SNPs in the human IL1B gene: evidence from bioinformatics analyses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.