Article
Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease).
Journal of medical genetics - 1 Jul 2006
Abrera-Abeleda M A, Nishimura C, Smith J L H, Sethi S, McRae J L, Murphy B F, Silvestri G, Skerka C, Józsi M, Zipfel P F, Hageman G S, Smith R J H
Abstract excerpt
INTRODUCTION: Membranoproliferative glomerulonephritis type II or dense deposit disease (MPGN II/DDD) causes chronic renal dysfunction that progresses to end stage renal disease in about half of patients within 10 years of diagnosis. Deficiency of and mutations in the complement factor H (CFH) gene are associated with the development of MPGN II/DDD, suggesting that dysregulation of the alternative pathway of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.