Article
Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.
Science (New York, N.Y.) - 18 Aug 2000
Li H, Kolluri S K, Gu J, Dawson M I, Cao X, Hobbs P D, Lin B, Chen G, Lu J, Lin F, Xie Z, Fontana J A, Reed J C, Zhang X
Abstract excerpt
TR3, an immediate-early response gene and an orphan member of the steroid-thyroid hormone-retinoid receptor superfamily of transcription factors, regulates apoptosis through an unknown mechanism. In response to apoptotic stimuli, TR3 translocates from the nucleus to mitochondria to induce cytochrome c release and apoptosis. Mitochondrial targeting of TR3, but not its DNA binding and transactivation, is essential...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.